Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes.
Fiche publication
Date publication
novembre 2021
Journal
RSC advances
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CIANFERANI Sarah, Dr WAGNER Alain, Dr CHAUBET Guilhem
Tous les auteurs :
Rady T, Mosser M, Nothisen M, Erb S, Dovgan I, Cianférani S, Wagner A, Chaubet G
Lien Pubmed
Résumé
Bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue - BCN acid - whose facile functionalization amide bond formation yields more stable derivatives than the classically encountered carbamates.
Référence
RSC Adv. 2021 Nov 10;11(58):36777-36780