Localized Enzyme-Assisted Self-Assembly of low molecular weight hydrogelators. Mechanism, applications and perspectives.
Fiche publication
Date publication
avril 2022
Journal
Advances in colloid and interface science
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHAAF Pierre
Tous les auteurs :
Muller C, Ontani A, Bigo-Simon A, Schaaf P, Jierry L
Lien Pubmed
Résumé
Nature uses systems of high complexity coordinated by the precise spatial and temporal control of associated processes, working from the molecular to the macroscopic scale. This living organization is mainly ensured by enzymatic actions. Herein, we review the concept of Localized Enzyme-Assisted Self-Assembly (LEASA). It is defined and presented as a straightforward and insightful strategy to achieve high levels of control in artificial systems. Indeed, the use of immobilized enzymes to drive self-assembly events leads not only to the local formation of supramolecular structures but also to tune their kinetics and their morphologies. The possibility to design tailored complex systems taking advantage of self-assembled networks through their inherent and emergent properties offers new perspectives for the design of novel, more adaptable materials. As a result, some applications have already been developed and are gathered in this review. Finally, challenges and perspectives of LEASA are introduced and discussed.
Mots clés
Enzyme, Hydrogels, Low molecular weight hydrogelator, Self-assembly, Spatiotemporal control
Référence
Adv Colloid Interface Sci. 2022 Apr 4;304:102660