Signaling Induced by Chronic Viral Hepatitis: Dependence and Consequences.
Fiche publication
Date publication
mars 2022
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas, Dr LUPBERGER Joachim, Dr VERRIER Eloi
Tous les auteurs :
Boulahtouf Z, Virzì A, Baumert TF, Verrier ER, Lupberger J
Lien Pubmed
Résumé
Chronic viral hepatitis is a main cause of liver disease and hepatocellular carcinoma. There are striking similarities in the pathological impact of hepatitis B, C, and D, although these diseases are caused by very different viruses. Paired with the conventional study of protein-host interactions, the rapid technological development of -omics and bioinformatics has allowed highlighting the important role of signaling networks in viral pathogenesis. In this review, we provide an integrated look on the three major viruses associated with chronic viral hepatitis in patients, summarizing similarities and differences in virus-induced cellular signaling relevant to the viral life cycles and liver disease progression.
Mots clés
HBV, HCV, HDV, cancer, fibrosis, inflammation, liver, metabolic disease, oxidative stress
Référence
Int J Mol Sci. 2022 Mar 3;23(5):