The β1-Adrenergic Receptor Contributes to Sepsis-Induced Immunosuppression Through Modulation of Regulatory T-Cell Inhibitory Function.
Fiche publication
Date publication
février 2022
Journal
Critical care medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GAUCHOTTE Guillaume
Tous les auteurs :
Durand M, Hagimont E, Louis H, Asfar P, Frippiat JP, Singer M, Gauchotte G, Labat C, Lacolley P, Levy B, Glenn Chousterman B, Kimmoun A
Lien Pubmed
Résumé
Although cardiovascular benefits ofβ1-adrenergic receptor blockade have been described in sepsis, little is known about its impact on the adaptive immune response, specifically CD4 T cells. Herein, we study the effects of β1-adrenergic receptor modulation on CD4 T-cell function in a murine model of sepsis.
Référence
Crit Care Med. 2022 Feb 18;: