The sustained PGE release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model.
Fiche publication
Date publication
février 2022
Journal
Journal of nanobiotechnology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BENKIRANE-JESSEL Nadia
Tous les auteurs :
Huang H, Chen S, Cheng H, Cao J, Du W, Zhang J, Chang Y, Shen X, Guo Z, Han Z, Hua G, Han ZC, Benkirane-Jessel N, Chang Y, Li Z
Lien Pubmed
Résumé
The promising therapeutic strategy for the treatment of peripheral artery disease (PAD) is to restore blood supply and promote regeneration of skeletal muscle regeneration. Increasing evidence revealed that prostaglandin E (PGE), a lipid signaling molecule, has significant therapeutic potential for tissue repair and regeneration. Though PGE has been well reported in tissue regeneration, the application of PGE is hampered by its short half-life in vivo and the lack of a viable system for sustained release of PGE.
Mots clés
Angiogenesis, Hindlimb ischemia (HI), Molecular imaging, Muscle regeneration, MyoD1, Prostaglandin E2 (PGE2), Sustained release
Référence
J Nanobiotechnology. 2022 Feb 24;20(1):95