Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups.
Fiche publication
Date publication
novembre 2018
Journal
Journal of clinical medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MUELLER Christopher
Tous les auteurs :
Navet B, Vargas-Franco JW, Gama A, Amiaud J, Choi Y, Yagita H, Mueller CG, Rédini F, Heymann D, Castaneda B, Lézot F
Lien Pubmed
Résumé
RANKL signalization is implicated in the morphogenesis of various organs, including the skeleton. Mice invalidated for present an osteopetrotic phenotype that was less severe than anticipated, depending on RANKL's implication in morphogenesis. The hypothesis of an attenuated phenotype, as a result of compensation during gestation by RANKL of maternal origin, was thus brought into question. In order to answer this question, null mutant pups from null mutant parents were generated, and the phenotype analyzed. The results validated the presence of a more severe osteopetrotic phenotype in the second-generation null mutant with perinatal lethality. The experiments also confirmed that RANKL signalization plays a part in the morphogenesis of skeletal elements through its involvement in cell-to-cell communication, such as in control of osteoclast differentiation. To conclude, we have demonstrated that the phenotype associated with invalidation is attenuated through compensation by RANKL of maternal origin.
Mots clés
RANKL, bone, mandible, morphogenesis, osteoclast, skeletal growth, tooth
Référence
J Clin Med. 2018 Nov 8;7(11):