Impact of Inhaled Corticosteroids on the Modulation of Respiratory Defensive Reflexes During Artificial Limb Exercise in Ovalbumin-Sensitized Rabbits.
Fiche publication
Date publication
janvier 2021
Journal
Frontiers in physiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHENUEL Bruno, Pr POUSSEL Mathias
Tous les auteurs :
Basin S, Valentin S, Demoulin-Alexikova S, Demoulin B, Foucaud L, Gérard D, Pouget C, Allado E, Chenuel B, Poussel M
Lien Pubmed
Résumé
Cough is a major lower airway defense mechanism that can be triggered by exercise in asthma patients. Studies on cough reflex in experimental animal models revealed a decrease of cough reflex sensitivity during exercise in healthy animals, but a lack of desensitization in ovalbumin-sensitized rabbits. The aim of our study is to evaluate the impact of inhaled corticosteroids on cough reflex during artificial limb exercise in an animal model of eosinophilic airway inflammation.
Mots clés
asthma, corticosteroids (CS), cough, defensive reflex, exercise
Référence
Front Physiol. 2021 ;12:804577