A phase II study of Navitoclax (ABT-263) as single agent in women heavily pretreated for recurrent epithelial ovarian cancer: The MONAVI - GINECO study.
Fiche publication
Date publication
février 2022
Journal
Gynecologic oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GAVOILLE Céline
Tous les auteurs :
Joly F, Fabbro M, Follana P, Lequesne J, Medioni J, Lesoin A, Frenel JS, Abadie-Lacourtoisie S, Floquet A, Gladieff L, You B, Gavoille C, Kalbacher E, Briand M, Brachet PE, Giffard F, Weiswald LB, Just PA, Blanc-Fournier C, Leconte A, Clarisse B, Leary A, Poulain L
Lien Pubmed
Résumé
There are limited treatment options for ovarian cancer patients with early relapse after platinum chemotherapy. In preclinical studies, we previously demonstrated the promising activity of ABT-737, a Bcl-2/Bcl-x anti-apoptotic protein inhibitor, in chemo-resistant ovarian cancer cells and tumors, suggesting its potential activity in platinum-resistant patients.
Mots clés
BH3 mimetics, Early phase study, Ovarian cancer, Platinum resistance
Référence
Gynecol Oncol. 2022 Feb 2;: