Performance evaluation of the IRIS XL-220 PET/CT system, a new camera dedicated to non-human primates.
Fiche publication
Date publication
février 2022
Journal
EJNMMI physics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BRASSE David
Tous les auteurs :
Boisson F, Serriere S, Cao L, Bodard S, Pilleri A, Thomas L, Sportelli G, Vercouillie J, Emond P, Tauber C, Belcari N, Lefaucheur JL, Brasse D, Galineau L
Lien Pubmed
Résumé
Non-human primates (NHP) are critical in biomedical research to better understand the pathophysiology of diseases and develop new therapies. Based on its translational and longitudinal abilities along with its non-invasiveness, PET/CT systems dedicated to non-human primates can play an important role for future discoveries in medical research. The aim of this study was to evaluate the performance of a new PET/CT system dedicated to NHP imaging, the IRIS XL-220 developed by Inviscan SAS. This was performed based on the National Electrical Manufacturers Association (NEMA) NU 4-2008 standard recommendations (NEMA) to characterize the spatial resolution, the scatter fraction, the sensitivity, the count rate, and the image quality of the system. Besides, the system was evaluated in real conditions with two NHP with F-FDG and (-)-[F]FEOBV which targets the vesicular acetylcholine transporter, and one rat using F-FDG.
Mots clés
Instrumentation, NEMA characterization, Non-human primates, PET/CT, Performance evaluation, Preclinical imaging
Référence
EJNMMI Phys. 2022 Feb 5;9(1):10