ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer.
Fiche publication
Date publication
janvier 2021
Journal
Frontiers in cell and developmental biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POLETTE Myriam, Dr NAWROCKI-RABY Béatrice, Dr DORMOY Valerian
Tous les auteurs :
Neyrinck-Leglantier D, Lesage J, Blacher S, Bonnomet A, Hunziker W, Noël A, Dormoy V, Nawrocki-Raby B, Gilles C, Polette M
Lien Pubmed
Résumé
Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. , we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. , we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression.
Mots clés
ZO-1, epithelial plasticity, epithelial-mesenchymal transition, immune infiltrate, lung cancer, tumor microenvironment
Référence
Front Cell Dev Biol. 2021 ;9:749364