Frequent, quantitative bone planar scintigraphy for determination of bone anabolism in growing mice.
Fiche publication
Date publication
janvier 2021
Journal
PeerJ
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak
Tous les auteurs :
Zaloszyc A, Schmitt CP, Sayeh A, Higel L, Gros CI, Bornert F, Aubertin-Kirch G, Dillenseger JP, Goetz C, Constantinesco A, Fischbach M, Bahram S, Choquet P
Lien Pubmed
Résumé
To provide insight into bone turnover, quantitative measurements of bone remodeling are required. Radionuclide studies are widely used in clinical care, but have been rarely used in the exploration of the bone in preclinical studies. We describe a bone planar scintigraphy method for frequent assessment of bone activity in mice across the growing period. Since repeated venous radiotracer injections are hardly feasible in mice, we investigated the subcutaneous route.
Mots clés
Growth, Mice, Radionuclide imaging, Subcutaneous application
Référence
PeerJ. 2021 ;9:e12355