The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms.

Fiche publication


Date publication

décembre 2021

Journal

Life (Basel, Switzerland)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GINDRAUX Florelle


Tous les auteurs :
Stati G, Passaretta F, Gindraux F, Centurione L, Di Pietro R

Résumé

In the framework of space flight, the risk of radiation carcinogenesis is considered a "red" risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after space missions. The cyclic AMP response element-binding protein (CREB) is overexpressed both in haematological malignancies and solid tumours and its expression and function are modulated following irradiation. The CREB protein is a transcription factor and member of the CREB/activating transcription factor (ATF) family. As such, it has an essential role in a wide range of cell processes, including cell survival, proliferation, and differentiation. Among the CREB-related nuclear transcription factors, NF-κB and p53 have a relevant role in cell response to ionising radiation. Their expression and function can decide the fate of the cell by choosing between death or survival. The aim of this review was to define the role of the CREB/ATF family members and the related transcription factors in the response to ionising radiation of human haematological malignancies and solid tumours.

Mots clés

CREB/ATF, NF-κB, galactic cosmic rays, human cancer, ionising radiation, radioresistance, radiotherapy, space flight

Référence

Life (Basel). 2021 Dec 20;11(12):