Long-Term Effects of Prematurity on Resting Ventilatory Response to Hypercapnia.
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Date publication
décembre 2021
Journal
High altitude medicine & biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POUSSEL Mathias
Tous les auteurs :
Manferdelli G, Narang BJ, Poussel M, Osredkar D, Millet GP, Debevec T
Lien Pubmed
Résumé
Manferdelli, Giorgio, Benjamin J. Narang, Mathias Poussel, Damjan Osredkar, Grégoire P. Millet, and Tadej Debevec. Long-term effects of prematurity on resting ventilatory response to hypercapnia. . 22:420-425, 2021. This study investigated the resting ventilatory response to hypercapnia in prematurely born adults. Seventeen preterm and fourteen full-term adults were exposed to normoxic hypercapnia (two 5-minute periods at 3% and 6% carbon dioxide [CO] interspersed by 5-minute in normoxia). Pulmonary ventilation ([Formula: see text]) and end-tidal partial pressure of CO (Petco) were measured continuously. No difference in lung function was observed between preterm and full-term adults. Petco was lower in preterm than in full-term adults ( < 0.05) during normoxia. During exposure to 3% CO, both [Formula: see text] and Petco increased in a similar way in preterm and full-term adults. However, at the end of the 6% CO period, there was a significantly higher [Formula: see text] in preterm compared with full-term adults (30.2 ± 7.5 vs. 23.7 ± 4.5 L/min, < 0.0001), whereas no difference was observed for Petco (46.9 ± 2.1 vs. 50.6 ± 2.1 L/min, = 0.99). Breath frequency was higher in preterm than in full-term adults (17.9 ± 4.0 vs. 12.8 ± 3.5 b/min, < 0.01) during 6% CO exposure. Although data suggest that prematurity results in resting hypocapnia, the exact underlying mechanisms remain to be elucidated. Moreover, preterm adults seem to have increased chemosensitivity to hypercapnia.
Mots clés
CO2, chemosensitivity, hypoxemia, preterm birth, respiration
Référence
High Alt Med Biol. 2021 Dec;22(4):420-425