Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells.
Fiche publication
Date publication
décembre 2021
Journal
Cell & bioscience
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BLAISE Sébastien, Dr DUCA Laurent, Pr MARTINY Laurent, Dr TERRYN Christine, Dr BENNASROUNE Amar
Tous les auteurs :
Bocquet O, Tembely D, Rioult D, Terryn C, Romier B, Bennasroune A, Blaise S, Sartelet H, Martiny L, Duca L, Maurice P
Lien Pubmed
Résumé
Vascular aging is associated with remodeling of elastin, one of the main extracellular matrix component of the arterial wall, and production of elastin-derived peptides (EDP). These extracellular matrix degradation products have been shown to trigger biological activities through the elastin receptor complex (ERC) and data from the last decade have brought significant insights on the critical role played by its NEU1 subunit in the biological effects mediated by EDP and the ERC in vascular and metabolic diseases.
Mots clés
Desialylation, Elastin peptides, Elastin receptor complex, Elastin remodeling, Endothelial cells, Membrane glycoproteins, Monocytes, NEU1
Référence
Cell Biosci. 2021 Dec 13;11(1):206