Brewer's yeast polysaccharides - A review of their exquisite structural features and biomedical applications.
Fiche publication
Date publication
février 2022
Journal
Carbohydrate polymers
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANO João F.
Tous les auteurs :
Bastos R, Oliveira PG, Gaspar VM, Mano JF, Coimbra MA, Coelho E
Lien Pubmed
Résumé
Recent advances on brewer's yeast cell wall polysaccharides have unraveled exquisite structural features and diverse composition with (β1→3), (β1→6), (α1→4), (β1→4)-mix-linked glucans that are recognized to interact with different cell receptors and trigger specific biological responses. Herein, a comprehensive showcase of structure-biofunctional relationships between yeast polysaccharides and their biological targets is highlighted, with a focus on polysaccharide features that govern the biomedical activity. The insolubility of β-glucans is a crucial factor for binding and activation of Dectin-1 receptor, operating as adjuvants of immune responses. Contrarily, soluble low molecular weight β-glucans have a strong inhibition of reactive oxygen species production, acting as antagonists of Dectin-1 mediated signaling. Soluble glucan-protein moieties can also act as antitumoral agents. The balance between mannoproteins-TLR2 and β-glucans-Dectin-1 receptors-activation is crucial for osteogenesis. Biomedical applications value can also be obtained from yeast microcapsules as oral delivery systems, where highly branched (β1→6)-glucans lead to higher receptor affinity.
Mots clés
Beta-glucan, Brewer's spent yeast, Drug delivery, Mannoprotein, Microcapsule, Regenerative medicine
Référence
Carbohydr Polym. 2022 Feb 1;277:118826