Electron-Beam-Induced Grafting of Chitosan onto HDPE/ATZ Composites for Biomedical Applications.

Fiche publication


Date publication

novembre 2021

Journal

Polymers

Auteurs

Membres identifiés du Cancéropôle Est :
Pr COQUERET Xavier


Tous les auteurs :
Faga MG, Duraccio D, Di Maro M, Kowandy C, Malucelli G, Mussano FD, Genova T, Coqueret X

Résumé

The surface functionalisation of high-density polyethylene (HDPE) and HDPE/alumina-toughened zirconia (ATZ) surfaces with chitosan via electron-beam (EB) irradiation technique was exploited for preparing materials suitable for biomedical purposes. ATR-FTIR analysis and wettability measurements were employed for monitoring the surface changes after both irradiation and chitosan grafting reaction. Interestingly, the presence of ATZ loadings beyond 2 wt% influenced both the EB irradiation process and the chitosan functionalisation reaction, decreasing the oxidation of the surface and the chitosan grafting. The EB irradiation induced an increase in Young's modulus and a decrease in the elongation at the break of all analysed systems, whereas the tensile strength was not affected in a relevant way. Biological assays indicated that electrostatic interactions between the negative charges of the surface of cell membranes and the -NH sites on chitosan chains promoted cell adhesion, while some oxidised species produced during the irradiation process are thought to cause a detrimental effect on the cell viability.

Mots clés

alumina-toughened zirconia (ATZ), cell adhesion, chitosan, electron-beam irradiation, high-density polyethylene (HDPE), mechanical properties, nano-roughness, radiation-induced grafting, viability, wettability

Référence

Polymers (Basel). 2021 Nov 20;13(22):