Joint modelling with competing risks of dropout for longitudinal analysis of health-related quality of life in cancer clinical trials.
Fiche publication
Date publication
novembre 2021
Journal
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CONROY Thierry
Tous les auteurs :
Cuer B, Conroy T, Juzyna B, Gourgou S, Mollevi C, Touraine C
Lien Pubmed
Résumé
Health-related quality of life (HRQoL) is an important endpoint in cancer clinical trials. Analysis of HRQoL longitudinal data is plagued by missing data, notably due to dropout. Joint models are increasingly receiving attention for modelling longitudinal outcomes and the time-to-dropout. However, dropout can be informative or non-informative depending on the cause.
Mots clés
Clinical trials, Competing risks, Health-related quality of life, Joint modelling, Missing data, Oncology
Référence
Qual Life Res. 2021 Nov 24;: