Monitoring subcutaneous tumors using Mueller polarimetry: study on two types of tumors.
Fiche publication
Date publication
octobre 2021
Journal
Biomedical optics express
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BAGNARD Dominique
Tous les auteurs :
Varin B, Rehbinder J, Dellinger J, Heinrich C, Torzynski M, Spenlé C, Bagnard D, Zallat J
Lien Pubmed
Résumé
A better understanding of tumor development is crucial for treating cancer. Polarimetric imaging is an interesting alternative for monitoring subcutaneous tumors as it is non-invasive. In this study, a Mueller spectro-polarimeter is used to monitor tumor development on mice injected with non-pigmented breast cancer cells or with pigmented murine melanoma cells. Three stages of non-pigmented tumor development are revealed with three polarimetric parameters. These stages also appear for pigmented tumors, although less clearly. A halo of high depolarization surrounding the non-pigmented tumor in the first stage allows the outlining of the tumor. Considering polarimetric parameters, a biological interpretation is proposed.
Référence
Biomed Opt Express. 2021 Oct 1;12(10):6055-6065