[Impact of thoracic irradiation on cardiac structures].
Fiche publication
Date publication
octobre 2021
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ANTONI Delphine, Pr NOEL Georges, Dr LE FEVRE Clara
Tous les auteurs :
Eber J, Nannini S, Chambrelant I, Le Fèvre C, Noël G, Antoni D
Lien Pubmed
Résumé
Thoracic irradiation requires protection of the heart as an organ at risk of complications. The mean heart dose is the most studied dosimetric parameter in the literature. Recent studies question its relevance in view of the multiplicity of cardiac injuries, the heterogeneity of the cardiac dose distribution and the current technical possibilities to refine cardiac dosimetric protection. The objective of this literature review is to analyze the available scientific data on the impact of the dose received by the cardiac substructures. A search of articles using the PubMed search engine was used to select the most relevant studies. A total of 19 articles were selected according to pre-established criteria to answer the issue. Several studies found significant associations between dosimetric parameters of substructures and clinical cardiological impact. Some proposed dose constraints for substructures.
Mots clés
Breast Cancer, Cancer du sein, Cancer pulmonaire, Cardiotoxicity, Cœur, Heart, Lung Cancer, Radiotherapy, Radiothérapie, Toxicité cardiaque
Référence
Cancer Radiother. 2021 Oct 30;: