Protein-like particles through nanoprecipitation of mixtures of polymers of opposite charge.
Fiche publication
Date publication
septembre 2021
Journal
Journal of colloid and interface science
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KLYMCHENKO Andrey
Tous les auteurs :
Combes A, Tang KN, Klymchenko AS, Reisch A
Lien Pubmed
Résumé
Polymer nanoparticles (NPs) have a very high potential for applications notably in the biomedical field. However, synthetic polymer NPs cannot yet concurrence the functionalities of proteins, their natural counterparts, notably in terms of size, control over internal structure and interactions with biological environments. We hypothesize that kinetic trapping of polymers bearing oppositely charged groups in NPs could bring a new level of control and allow mimicking the surfaces of proteins.
Mots clés
Fluorescent nanoparticles, Mixed-charge nanoparticles, Nanoparticle surface chemistry, Nanoprecipitation, Polymer nanoparticles
Référence
J Colloid Interface Sci. 2021 Sep 20;607(Pt 2):1786-1795