Investigation of antiparasitic activity of ten European tree bark extracts on and bioguided identification of triterpenes in barks.
Fiche publication
Date publication
octobre 2021
Journal
Antimicrobial agents and chemotherapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DEBELLE Laurent, Pr VILLENA Isabelle
Tous les auteurs :
Darme P, Spalenka J, Hubert J, Escotte-Binet S, Debelle L, Villena I, Sayagh C, Borie N, Martinez A, Bertaux B, Voutquenne-Nazabadioko L, Renault JH, Aubert D
Lien Pubmed
Résumé
Toxoplasmosis is a worldwide parasitosis that affects one-third of the population. People at risk, such as immunocompromised patients (AIDS, chemotherapy treatment) or fetuses (maternal-fetal transmission) can develop severe forms of the disease. The antiparasitic activity of extracts of different polarities (-heptane, MeOH, MeOH/HO) of ten tree species endemics to temperate regions was investigated against infection . Our results showed that the -heptane extract of the black alder () exhibited a significant antiparasitic activity without any cytotoxicity at the tested concentrations, with an IC of up to 25.08 μg/mL and a selectivity index higher than 3.99. The chemical profiling of this extract revealed triterpenes as major constituents. The ability of commercially available triterpene (betulin, betulinic acid, and betulone) to inhibit the growth of was evaluated and showed growth inhibition rates of 44%, 49%, and 99% at 10 μM, respectively.
Référence
Antimicrob Agents Chemother. 2021 Oct 11;:AAC0109821