Neutrophil-to-lymphocyte ratio is correlated to driver gene mutations in surgically-resected non-small cell lung cancer and its post-operative evolution impacts outcomes.
Fiche publication
Date publication
août 2021
Journal
Clinical lung cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FALCOZ Pierre-Emmanuel, Pr GAUCHOTTE Guillaume
Tous les auteurs :
Seitlinger J, Prieto M, Guerrera F, Streit A, Gauchotte G, Siat J, Falcoz PE, Massard G, Ferri L, Spicer J, Renaud S
Lien Pubmed
Résumé
We sought to evaluate prognostic value of neutrophil-to-lymphocyte ratio (NLR) in surgically resected non-small cell lung cancer (NSCLC) and its correlation to oncogenic drivers. We retrospectively reviewed data of patients who underwent anatomic lung resection for NSCLC and whose mutational status was known, from 4 department of thoracic surgery, over the period 2008 to 2019. Primary endpoints were overall survival (OS) and time to recurrence (TTR). Clinical and molecular factors were investigated in the univariate and multivariate analysis for their association with the primary endpoints.
Mots clés
Biomarker, Lung cancer, Mutational status, Neutrophil to lymphocyte ratio, Surgery
Référence
Clin Lung Cancer. 2021 Aug 22;: