Impact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status.
Fiche publication
Date publication
septembre 2021
Journal
Cells
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LIZARD Gérard
Tous les auteurs :
de Freitas FA, Levy D, Zarrouk A, Lizard G, Bydlowski SP
Lien Pubmed
Résumé
Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-enzymatic pathways (auto-oxidation). The oxidation processes lead to the synthesis of about 60 different oxysterols. Several oxysterols have physiological, pathophysiological, and pharmacological activities. The effects of oxysterols on cell death processes, especially apoptosis, autophagy, necrosis, and oxiapoptophagy, as well as their action on cell proliferation, are reviewed here. These effects, also observed in several cancer cell lines, could potentially be useful in cancer treatment. The effects of oxysterols on cell differentiation are also described. Among them, the properties of stimulating the osteogenic differentiation of mesenchymal stem cells while inhibiting adipogenic differentiation may be useful in regenerative medicine.
Mots clés
apoptosis, autophagy, cell death, differentiation, mesenchymal stem cells, oxiapoptophagy, oxysterols
Référence
Cells. 2021 Sep 3;10(9):