Antimicrobial Peptides: A Potent Alternative to Antibiotics.
Fiche publication
Date publication
septembre 2021
Journal
Antibiotics (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BECHINGER Burkhard
Tous les auteurs :
Rima M, Rima M, Fajloun Z, Sabatier JM, Bechinger B, Naas T
Lien Pubmed
Résumé
Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.
Mots clés
ESKAPE, antibiotic resistance, antimicrobial peptides, multidrug resistance
Référence
Antibiotics (Basel). 2021 Sep 10;10(9):