3D-bioprinted cancer-on-a-chip: level-up organotypic in vitro models.
Fiche publication
Date publication
septembre 2021
Journal
Trends in biotechnology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANO João F.
Tous les auteurs :
Monteiro MV, Zhang YS, Gaspar VM, Mano JF
Lien Pubmed
Résumé
Combinatorial conjugation of organ-on-a-chip platforms with additive manufacturing technologies is rapidly emerging as a disruptive approach for upgrading cancer-on-a-chip systems towards anatomic-sized dynamic in vitro models. This valuable technological synergy has potential for giving rise to truly physiomimetic 3D models that better emulate tumor microenvironment elements, bioarchitecture, and response to multidimensional flow dynamics. Herein, we showcase the most recent advances in bioengineering 3D-bioprinted cancer-on-a-chip platforms and provide a comprehensive discussion on design guidelines and possibilities for high-throughput analysis. Such hybrid platforms represent a new generation of highly sophisticated 3D tumor models with improved biomimicry and predictability of therapeutics performance.
Mots clés
3D bioprinting, cancer-on-a-chip, in vitro tumor models, preclinical drug screening
Référence
Trends Biotechnol. 2021 Sep 20;: