Pioneer Factors and Architectural Proteins Mediating Embryonic Expression Signatures in Cancer.
Fiche publication
Date publication
avril 2019
Journal
Trends in molecular medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BARRETO Guillermo
Tous les auteurs :
Dobersch S, Rubio K, Barreto G
Lien Pubmed
Résumé
Accumulation of mutations causing aberrant changes in the genome promotes cancer. However, mutations do not occur in every cancer subtype, suggesting additional events that trigger cancer. Chromatin rearrangements initiated by pioneer factors and architectural proteins are key events occurring before cancer-related genes are expressed. Both protein groups are also master regulators of important processes during embryogenesis. Several publications demonstrated that embryonic gene expression signatures are reactivated during cancer. This review article highlights current knowledge on pioneer factors and architectural proteins mediating chromatin rearrangements, which are the backbone of embryonic expression signatures promoting malignant transformation. Understanding chromatin rearrangements inducing embryonic expression signatures in adult cells might be the key to novel therapeutic approaches against cancers subtypes that arise without genomic mutations.
Mots clés
architectural proteins, cancer, embryonic, expression signature, pioneer factors
Référence
Trends Mol Med. 2019 04;25(4):287-302