Failure to Down-Regulate Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-β Signaling Similar to those Induced by Exposure to Hyperoxia.
Fiche publication
Date publication
avril 2020
Journal
Cells
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BARRETO Guillermo
Tous les auteurs :
Chao CM, Carraro G, Rako ZA, Kolck J, Sedighi J, Zimmermann V, Moiseenko A, Wilhelm J, Young BM, Chong L, Wu J, Contreras A, Minoo P, Barreto G, Warburton D, Bellusci S
Lien Pubmed
Résumé
Bronchopulmonary dysplasia (BPD) is a lung disease of preterm born infants, characterized by alveolar simplification. MicroRNA ( are known to be involved in many biological and pathological processes in the lung. Although a changed expression has been described for several in BPD, a causal role remains to be established.
Mots clés
AT2, Caveolin1, Tgf-ß1, alveolar simplification, hyperoxia, miR-154
Référence
Cells. 2020 04 2;9(4):