TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer.
Fiche publication
Date publication
août 2021
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent, Dr BOIDOT Romain, Pr GHIRINGHELLI François, Mme TRUNTZER Caroline, Dr DERANGERE Valentin, Dr FUMET Jean-David
Tous les auteurs :
Lecuelle J, Boidot R, Mananet H, Derangère V, Albuisson J, Goussot V, Arnould L, Tharin Z, Ray Coquard I, Ghiringhelli F, Truntzer C, Fumet JD
Lien Pubmed
Résumé
Immune infiltration is a prognostic factor in high-grade serous ovarian carcinoma (HGSC) but immunotherapy efficacy is disappointing. Genomic instability is now used to guide the therapeutic value of PARP inhibitors. We aimed to investigate exome-derived parameters to assess the tumor microenvironment according to genomic instability profile.
Mots clés
HGSC, HRD, TCR clonality, biomarkers, prognostic
Référence
Cancers (Basel). 2021 Aug 31;13(17):