[Histopathological diagnosis of an intoxication].
Fiche publication
Date publication
septembre 2021
Journal
Annales de pathologie
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LHERMITTE Benoît, Dr GANTZER Justine
Tous les auteurs :
Fattori A, Arfeuille G, Parratte T, Gantzer J, Olagne J, Lannes B, Lhermitte B
Lien Pubmed
Résumé
Ethylene glycol poisoning is relatively rare, with around a hundred cases reported each year in France. Its diagnosis is often challenging and delayed because of a several hours' free interval between ingestion of the toxic and the onset of the first symptoms. Ethylene glycol is a colorless and odorless liquid primarily found in automotive coolants, whose toxicity is linked to its hepatic metabolites. Histologically, ethylene glycol poisoning is characterized by abundant tissular deposits of calcium oxalate crystals. Under polarized light, these crystals appear birefringent and iridescent. Their microscopic appearance and their distribution are pathognomonic of oxalosis. Due to its frequent misleading presentation, the diagnosis of ethylene glycol poisoning is sometimes only made after an autopsy. Hereafter, we report the case of a 59-year-old man diagnosed with ethylene glycol intoxication after a post-mortem histopathological examination of organs.
Mots clés
Autopsie, Autopsy, Ethylene glycol, Intoxication, Oxalose, Oxalosis, Poisoning, Éthylène glycol
Référence
Ann Pathol. 2021 Sep 2;: