Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae).
Fiche publication
Date publication
mai 2015
Journal
Journal of ethnopharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VILLA Pascal
Tous les auteurs :
Houël E, Fleury M, Odonne G, Nardella F, Bourdy G, Vonthron-Sénécheau C, Villa P, Obrecht A, Eparvier V, Deharo E, Stien D
Lien Pubmed
Résumé
Field investigations highlighted the use of Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh), a small tree used by the Wayana Amerindians in Twenke-Taluhwen and Antecume-Pata, French Guiana, for the treatment of malaria, and administered either orally in the form of a decoction or applied externally over the whole body. This use appears limited to the Wayana cultural group in French Guiana and has never been reported anywhere else. Our goal was to evaluate the antimalarial and anti-inflammatory activities of a P. acutangulum decoction to explain the good reputation of this remedy.
Mots clés
Animals, Anti-Inflammatory Agents, chemistry, Antimalarials, pharmacology, Antiprotozoal Agents, chemistry, Cell Line, Chloroquine, pharmacology, Ethnopharmacology, methods, French Guiana, Humans, Interleukins, metabolism, Leukocytes, Mononuclear, drug effects, Malaria, Falciparum, drug therapy, Mice, Myrtaceae, chemistry, Nitric Oxide, metabolism, Plant Extracts, chemistry, Plants, Medicinal, chemistry, Plasmodium falciparum, drug effects, Psidium, chemistry, Tumor Necrosis Factor-alpha, metabolism
Référence
J Ethnopharmacol. 2015 May;166:279-85