RNA Modifications in Pathogenic Bacteria: Impact on Host Adaptation and Virulence.
Fiche publication
Date publication
juillet 2021
Journal
Genes
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ROMBY Pascale
Tous les auteurs :
Antoine L, Bahena-Ceron R, Devi Bunwaree H, Gobry M, Loegler V, Romby P, Marzi S
Lien Pubmed
Résumé
RNA modifications are involved in numerous biological processes and are present in all RNA classes. These modifications can be constitutive or modulated in response to adaptive processes. RNA modifications play multiple functions since they can impact RNA base-pairings, recognition by proteins, decoding, as well as RNA structure and stability. However, their roles in stress, environmental adaptation and during infections caused by pathogenic bacteria have just started to be appreciated. With the development of modern technologies in mass spectrometry and deep sequencing, recent examples of modifications regulating host-pathogen interactions have been demonstrated. They show how RNA modifications can regulate immune responses, antibiotic resistance, expression of virulence genes, and bacterial persistence. Here, we illustrate some of these findings, and highlight the strategies used to characterize RNA modifications, and their potential for new therapeutic applications.
Mots clés
RNA modifications, host-adaptation, mRNA, pathogenic bacteria, ribosomal RNA, small non-coding RNA, stress adaptation, tRNA
Référence
Genes (Basel). 2021 Jul 24;12(8):