Heat Shock Proteins and exosomes in cancer theranostics.
Fiche publication
Date publication
juillet 2021
Journal
Seminars in cancer biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen, Dr GOBBO Jessica
Tous les auteurs :
Regimbeau M, Abrey J, Vautrot V, Causse S, Gobbo J, Garrido C
Lien Pubmed
Résumé
Heat shock proteins (HSPs) are a superfamily of molecular chaperones that were discovered through their ability to be induced by different stresses including heat shock. Other than their function as chaperones in proteins homeostasis, HSPs have been shown to inhibit different forms of cell death and to participate in cell proliferation and differentiation processes. Because cancer cells have to rewire their metabolism, they require a high amount of these stress-inducible chaperones for their survival. Therefore, HSPs are unusually abundant in cancer cells where they have oncogene-like functions. In cancer, HSPs have been involved in the regulation of apoptosis, immune responses, angiogenesis, metastasis and treatment resistance. Recently, HSPs have been shown to be secreted through exosomes by cancer cells. These tumor-derived exosomes can be used as circulating markers: HSP-exosomes have been reported as biomarkers of cancer dissemination, response to therapy and/or patient outcome. A new range of functions, mostly in modulation of anticancer immune responses, have been described for these extracellular HSPs. In this review, we will describe those recently reported functions of HSP-exosomes that makes them both targets for anticancer therapeutics and biomarkers for the monitoring of the disease. We will also discuss their emerging interest in cancer vaccines.
Mots clés
Cancer vaccines, Circulating biomarkers, Heat shock proteins, cancer therapy, exosomes
Référence
Semin Cancer Biol. 2021 Jul 31;: