Hypoxia in Lung Cancer Management: A Translational Approach.
Fiche publication
Date publication
juillet 2021
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DALSTEIN Véronique, Pr POLETTE Myriam, Dr NAWROCKI-RABY Béatrice, Dr DORMOY Valerian
Tous les auteurs :
Ancel J, Perotin JM, Dewolf M, Launois C, Mulette P, Nawrocki-Raby B, Dalstein V, Gilles C, Deslée G, Polette M, Dormoy V
Lien Pubmed
Résumé
Lung cancer represents the first cause of death by cancer worldwide and remains a challenging public health issue. Hypoxia, as a relevant biomarker, has raised high expectations for clinical practice. Here, we review clinical and pathological features related to hypoxic lung tumours. Secondly, we expound on the main current techniques to evaluate hypoxic status in NSCLC focusing on positive emission tomography. We present existing alternative experimental approaches such as the examination of circulating markers and highlight the interest in non-invasive markers. Finally, we evaluate the relevance of investigating hypoxia in lung cancer management as a companion biomarker at various lung cancer stages. Hypoxia could support the identification of patients with higher risks of NSCLC. Moreover, the presence of hypoxia in treated tumours could help clinicians predict a worse prognosis for patients with resected NSCLC and may help identify patients who would benefit potentially from adjuvant therapies. Globally, the large quantity of translational data incites experimental and clinical studies to implement the characterisation of hypoxia in clinical NSCLC management.
Mots clés
HIF, angiogenesis, hypoxia, lung cancer management, non-small cell lung cancer, oxygen sensing
Référence
Cancers (Basel). 2021 Jul 8;13(14):