Epigenetic Reprogramming of CD4 Helper T Cells as a Strategy to Improve Anticancer Immunotherapy.
Fiche publication
Date publication
janvier 2021
Journal
Frontiers in immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier, Pr BORG Christophe, Dr HERVOUET Eric, Dr PEIXOTO Paul, Dr LOYON Romain, Dr KROEMER Marie
Tous les auteurs :
Renaude E, Kroemer M, Borg C, Peixoto P, Hervouet E, Loyon R, Adotévi O
Lien Pubmed
Résumé
Evidences highlight the role of various CD4 helper T cells (CD4 Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4 Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4 T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4 Th responses by epigenetic drugs to improve anticancer immunotherapy.
Mots clés
CD4+ helper T cells, epigenetics, immunotherapy, plasticity, tumor microenvironment
Référence
Front Immunol. 2021 ;12:669992