GIP/MZT1 proteins orchestrate nuclear shaping.
Fiche publication
Date publication
janvier 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHMIT Anne-Catherine
Tous les auteurs :
Batzenschlager M, Herzog E, Houlne G, Schmit AC, Chaboute ME
Lien Pubmed
Résumé
The functional organization of the nuclear envelope (NE) is only just emerging in plants with the recent characterization of NE protein complexes and their molecular links to the actin cytoskeleton. The NE also plays a role in microtubule nucleation by recruiting gamma-Tubulin Complexes (gamma-TuCs) which contribute to the establishment of a robust mitotic spindle. gamma-tubulin Complex Protein 3 (GCP3)-interacting proteins (GIPs) have been identified recently as integral components of gamma-TuCs. GIPs have been conserved throughout evolution and are also named MZT1 (mitotic-spindle organizing protein 1). This review focuses on recent data investigating the role of GIP/MZT1 at the NE, including insights from the study of GIP partners. It also uncovers new functions for GIP/MZT1 during interphase and highlights a current view of NE-associated components which are critical for nuclear shaping during both cell division and differentiation.
Référence
Front Plant Sci. 2014 Feb 7;5:29