Inflammatory and immunological profile in COPD secondary to organic dust exposure.
Fiche publication
Date publication
juillet 2021
Journal
Clinical immunology (Orlando, Fla.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier, Mme LAHEURTE Caroline
Tous les auteurs :
Keddache S, Laheurte C, Boullerot L, Laurent L, Dalphin JC, Adotevi O, Soumagne T
Lien Pubmed
Résumé
Inflammatory response in patients with COPD secondary to organic dust exposure (OD-COPD) is poorly understood. We therefore aimed to characterize inflammatory and immune profile from peripheral blood mononuclear cells (PBMC) in a group of patients with mild-to-moderate COPD secondary to organic dust exposure (OD-COPD), tobacco smoking (T-COPD), or both. We compared T, B and NK cells distribution and inflammatory (TNF-α, Il-1β, IL-6), type 1 (IFN-γ), type 2 (IL-4, IL-13) and type 3 (IL-17) immunity related cytokines at baseline, and after stimulation with LPS, flagellin and CD3/CD28 beads in all COPD groups. OD-COPD displayed significantly lower NK cells and CD8+ T cells compared with controls. After flagellin stimulation, T-COPD had significantly lower IL-13 levels than OD-COPD and controls (p < 0.05) whereas IFN-γ tended to be lower in OD-COPD. All COPD groups displayed higher IL-1β and IL-17 than controls after CD3/CD28 stimulation. Inflammatory responses in OD-COPD were different from T-COPD. OD-COPD displayed higher levels of type 2 immunity related cytokines.
Mots clés
Chronic obstructive pulmonary disease, Cytokines, Inflammation, Organic dust
Référence
Clin Immunol. 2021 Jul 16;:108798