Primary ciliogenesis is a crucial step for multiciliated cell determinism in the respiratory epithelium.
Fiche publication
Date publication
juin 2021
Journal
Journal of cellular and molecular medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POLETTE Myriam, Dr DORMOY Valerian
Tous les auteurs :
Belgacemi R, Diabasana Z, Hoarau A, Dubernard X, Mérol JC, Ruaux C, Polette M, Perotin JM, Deslée G, Dormoy V
Lien Pubmed
Résumé
The alteration of the mucociliary clearance is a major hallmark of respiratory diseases related to structural and functional cilia abnormalities such as chronic obstructive pulmonary diseases (COPD), asthma and cystic fibrosis. Primary cilia and motile cilia are the two principal organelles involved in the control of cell fate in the airways. We tested the effect of primary cilia removal in the establishment of a fully differentiated respiratory epithelium. Epithelial barrier integrity was not altered while multiciliated cells were decreased and mucous-secreting cells were increased. Primary cilia homeostasis is therefore paramount for airway epithelial cell differentiation. Primary cilia-associated pathophysiologic implications require further investigations in the context of respiratory diseases.
Mots clés
airway epithelium, cell differentiation, cilia
Référence
J Cell Mol Med. 2021 Jun 25;: