A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value.
Fiche publication
Date publication
mai 2021
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHENARD Marie-Pierre, Dr CHOULIER Laurence, Dr DONTENWILL Monique, Pr ENTZ-WERLE Natacha, Dr GUERIN Eric, Pr NOEL Georges, Dr POCH Olivier, Dr LHERMITTE Benoît, Dr BURCKEL Hélène
Tous les auteurs :
Entz-Werlé N, Poidevin L, Nazarov PV, Poch O, Lhermitte B, Chenard MP, Burckel H, Guérin E, Fuchs Q, Castel D, Noel G, Choulier L, Dontenwill M, Van Dyck E
Lien Pubmed
Résumé
Pediatric high-grade gliomas (pHGGs) are the leading cause of mortality in pediatric neuro-oncology, displaying frequent resistance to standard therapies. Profiling DNA repair and cell cycle gene expression has recently been proposed as a strategy to classify adult glioblastomas. To improve our understanding of the DNA damage response pathways that operate in pHGGs and the vulnerabilities that these pathways might expose, we sought to identify and characterize a specific DNA repair and cell-cycle gene expression signature of pHGGs.
Mots clés
DNA damage repair, PARP1, XRCC1, pediatric high-grade gliomas, prognostic clustering
Référence
Cancers (Basel). 2021 May 7;13(9):