Dosing of losartan in men vs. women with HFrEF: the HEAAL trial.
Fiche publication
Date publication
mai 2021
Journal
European journal of heart failure
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ROSSIGNOL Patrick
Tous les auteurs :
Ferreira JP, Konstam MA, McMurray JJV, Butler J, Girerd N, Rossignol P, Sharma A, Voors AA, Lam CSP, Packer M, Zannad F
Lien Pubmed
Résumé
In heart failure with reduced ejection fraction (HFrEF), guidelines recommend up-titration of angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptors blockers (ARBs) to the maximum tolerated dose. However, some studies suggest that women might need lower doses of ACEi/ARBs than men to achieve similar treatment benefit.
Mots clés
dose-response, heart failure, machine learning, sex differences, treatment dose
Référence
Eur J Heart Fail. 2021 May 29;: