Engineering Strategies for Allogeneic Solid Tissue Acceptance.
Fiche publication
Date publication
avril 2021
Journal
Trends in molecular medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANO João F.
Tous les auteurs :
Sousa AR, Mano JF, Oliveira MB
Lien Pubmed
Résumé
Advances in allogeneic transplantation of solid organs and tissues depend on our understanding of mechanisms that mediate the prevention of graft rejection. For the past decades, clinical practice has established guidelines to prevent allograft rejection, which mostly rely on the intake of nontargeted immunosuppressants as the gold standard. However, such lifelong regimens have been reported to trigger severe morbidities and commonly fail in preventing late allograft loss. In this review, the biology of allogeneic rejection and self-tolerance is analyzed, as well as the mechanisms of cellular-based therapeutics driving suppression and/or tolerance. Bioinspired engineering strategies that take advantage of cells, biomaterials, or combinations thereof to prevent allograft rejection are addressed, as well as biological mechanisms that drive their efficacy.
Mots clés
allogeneic transplantation, bioengineering acceptance-inducing strategies, cellular/acellular therapeutics, tissue engineering
Référence
Trends Mol Med. 2021 Apr 14;: