Epigenetic regulation of genes involved in the reverse cholesterol transport through interaction with miRNAs.
Fiche publication
Date publication
juin 2018
Journal
Frontiers in bioscience (Landmark edition)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr RIHN Bertrand
Tous les auteurs :
Zaiou M, Rihn BH, Bakillah A
Lien Pubmed
Résumé
microRNAs (miRNAs) are a group of small non-coding RNA molecules known to regulate target genes at the post-transcriptional level. miRNAs are implicated in the regulation of multiple pathophysiological processes including dyslipidemia, a major risk factor for atherosclerosis. Emerging evidence suggests that miRNAs act as a novel class of epigenetic regulators of high-density lipoproteins cholesterol (HDL-C) from synthesis to clearance contributing remarkably to the pathogenesis of atherosclerosis. Accumulating studies have revealed that miRNAs such as miR-33, miR-27, miR-144, miR-758 and miR-20 are involved in the post-transcriptional control of ABCA1, ABCG1 and SCARB1 genes regulatory network of the reverse cholesterol transport (RCT). These miRNAs have been shown to be central players in the impairment of RCT pathway leading to the development of atherosclerosis. In this article, we present most recent understanding of involvement of relevant miRNAs in different steps of HDL metabolism and RCT pathway. We also discuss some of the actual limitations to the promise of these miRNAs and perspectives on their translation to clinical settings.
Mots clés
ATP Binding Cassette Transporter 1, genetics, ATP Binding Cassette Transporter, Subfamily G, Member 1, genetics, Animals, Atherosclerosis, genetics, Biological Transport, genetics, Cholesterol, metabolism, Cholesterol, HDL, metabolism, Epigenesis, Genetic, Gene Expression Regulation, Gene Regulatory Networks, Humans, Lipid Metabolism, genetics, MicroRNAs, genetics, Scavenger Receptors, Class B, genetics
Référence
Front Biosci (Landmark Ed). 2018 06 1;23:2090-2105