Sex differences in the evolution of neutralizing antibodies to SARS-CoV-2.
Fiche publication
Date publication
mars 2021
Journal
The Journal of infectious diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MEYER Nicolas, Dr MUTTER Catherine, Pr DE SEZE Jérôme
Tous les auteurs :
Grzelak L, Velay A, Madec Y, Gallais F, Staropoli I, Schmidt-Mutter C, Wendling MJ, Meyer N, Planchais C, Rey D, Mouquet H, Reix N, Glady L, Hansmann Y, Bruel T, De Séze J, Fontanet A, Gonzalez M, Schwartz O, Fafi-Kremer S
Lien Pubmed
Résumé
We measured Anti-Spike (S), Nucleoprotein (N) and neutralizing antibodies (NAbs) in sera from 308 RT-qPCR + healthcare workers with mild disease, collected at two time-points up to 6 months after symptom onset. At Month 1 (M1), anti-S and N antibody levels were higher in males > 50 years or with a body mass index (BMI) > 25. At M3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and NAbs declined faster in males than in females, independently of age and BMI, suggesting an association of sex with evolution of the humoral response.
Mots clés
COVID-19, SARS-CoV-2, antibodies, sex-related differences
Référence
J Infect Dis. 2021 Mar 7;: