Thyroid hormone regulation of intestinal epithelial stem cell biology.
Fiche publication
Date publication
décembre 2017
Journal
Molecular and cellular endocrinology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PLATEROTI Michelina
Tous les auteurs :
Frau C, Godart M, Plateroti M
Lien Pubmed
Résumé
The gastrointestinal tract is a well-characterized target of thyroid hormones and thyroid hormone nuclear receptors TRs, as extensively described in the literature. The paradigm is its important remodelling in amphibians during thyroid hormone-dependent metamorphosis. Interestingly, several studies have described the conservation of this hormonal signal during intestinal development in mammals. Additional data suggested that it may also play a role in intestinal homeostasis, stem cell physiology and progenitor commitment as well as in tumour development. It is worth underlining that in the mammalian intestine the functionality of the TRα1 receptor is coordinated and integrated with other signalling pathways, such as Wnt and Notch, specifically at the level of stem/progenitor cell populations. Here, we summarize these data and concepts and discuss this new role for thyroid hormones and the TRα1 receptor in the biology of intestinal epithelial precursor cells.
Mots clés
Intestinal epithelium, Stem cells, Thyroid hormone, Thyroid hormone receptor TR, Wnt and notch pathways
Référence
Mol Cell Endocrinol. 2017 Dec 25;459:90-97