Thyroid Hormone Receptors: Several Players for One Hormone and Multiple Functions.
Fiche publication
Date publication
janvier 2018
Journal
Methods in molecular biology (Clifton, N.J.)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PLATEROTI Michelina
Tous les auteurs :
Samarut J, Plateroti M
Lien Pubmed
Résumé
Thyroid hormone receptors (TRs) were cloned based on their homology with the retroviral oncogene v-ERBA. In Vertebrates two genes, THRA and THRB, encode respectively many isotypes and isoforms of receptors TRα and TRβ, resulting from alternative splicing and/or internal transcription start sites. We present here a wide overview of this diversity and of their mechanisms of action as transcription regulators, as well as alternative actions through cytoplasmic signaling.
Mots clés
Cytoplasmic signaling, THRA, THRB, Thyroid hormone receptors (TRs)
Référence
Methods Mol Biol. 2018 ;1801:1-8