Fabrication of Quasi-2D Shape-Tailored Microparticles using Wettability Contrast-Based Platforms.
Fiche publication
Date publication
février 2021
Journal
Advanced materials (Deerfield Beach, Fla.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANO João F.
Tous les auteurs :
Neto MD, Stoppa A, Neto MA, Oliveira FJ, Gomes MC, Boccaccini AR, Levkin PA, Oliveira MB, Mano JF
Lien Pubmed
Résumé
The ability to fabricate materials with ultrathin architectures enables the breakthrough of low-dimensional structures with high surface area that showcase distinctive properties from their bulk counterparts. They are exploited in a wide range of fields, including energy harvesting, catalysis, and biomedicine. Despite such versatility, the fine tuning of the lateral dimensions and geometry of these structures remains challenging. Prepatterned platforms gain significant attention as enabling technologies to process materials with highly controlled shapes and dimensions. Herein, different nanometer-thick particles of various lateral sizes and geometries (e.g., squares, circles, triangles, hexagons) are processed with high precision and definition, taking advantage of the wettability contrast of oleophilic-oleophobic patterned surfaces. Quasi-2D polymeric microparticles with high shape- and size-fidelity can be retrieved as freestanding objects in a single step. These structures show cell-mediated pliability, and their integration in gravity-enforced human adipose-derived stem cell spheroids leads to an enhanced metabolic activity and a modulated secretion of proangiogenic factors.
Mots clés
bioinspired surfaces, oleophobic patterned surfaces, quasi-2D nanostructures, ultrathin microparticles, wettable-dewettable contrast
Référence
Adv Mater. 2021 Feb 28;:e2007695