H3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy.
Fiche publication
Date publication
mars 2021
Journal
Stem cell research & therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MAGDALOU Jacques
Tous les auteurs :
Qi Y, Li B, Wen Y, Yang X, Chen B, He Z, Zhao Z, Magdalou J, Wang H, Chen L
Lien Pubmed
Résumé
Epidemiological investigation and our previous reports indicated that osteoarthritis had a fetal origin and was closely associated with intrauterine growth retardation (IUGR). Human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) could be programmable to "remember" early-life stimuli. Here, we aimed to explore an early-warning biomarker of fetal-originated adult osteoarthritis in the WJ-MSCs.
Mots clés
Biomarker, Chondrogenic differentiation, Osteoarthritis, Transforming growth factor β receptor I, Wharton’s jelly-derived mesenchymal stem cells
Référence
Stem Cell Res Ther. 2021 Mar 4;12(1):163