Overexpression of the Msk1 Kinase in Patients With Chronic Lung Allograft Dysfunction and its Confirmed Role in a Murine Model.
Fiche publication
Date publication
février 2020
Journal
Transplantation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VILLA Pascal
Tous les auteurs :
Nemska S, Daubeuf F, Obrecht A, Israel-Biet D, Stern M, Kessler R, Roux A, Tavakoli R, Villa P, Tissot A, Danger R, Reber L, Durand E, Foureau A, Brouard S, Magnan A, Frossard N,
Lien Pubmed
Résumé
Chronic lung allograft dysfunction (CLAD) and its obstructive form, the obliterative bronchiolitis (OB), are the main long-term complications related to high mortality rate post-lung transplantation. CLAD treatment lacks a significant success in survival. Here, we investigated a new strategy through inhibition of the pro-inflammatory Mitogen and Stress Activated Kinase 1 (MSK1) kinase.
Référence
Transplantation. 2020 Feb 3;: