Cu-Doped ZnO Nanoparticles for Non-Enzymatic Glucose Sensing.
Fiche publication
Date publication
février 2021
Journal
Molecules (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MILLOT Nadine, Dr BOUDON Julien
Tous les auteurs :
Mahmoud A, Echabaane M, Omri K, Boudon J, Saviot L, Millot N, Chaabane RB
Lien Pubmed
Résumé
Copper-doped zinc oxide nanoparticles (NPs) CuZnO ( = 0, 0.01, 0.02, 0.03, and 0.04) were synthesized via a sol-gel process and used as an active electrode material to fabricate a non-enzymatic electrochemical sensor for the detection of glucose. Their structure, composition, and chemical properties were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) and Raman spectroscopies, and zeta potential measurements. The electrochemical characterization of the sensors was studied using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). Cu doping was shown to improve the electrocatalytic activity for the oxidation of glucose, which resulted from the accelerated electron transfer and greatly improved electrochemical conductivity. The experimental conditions for the detection of glucose were optimized: a linear dependence between the glucose concentration and current intensity was established in the range from 1 nM to 100 μM with a limit of detection of 0.7 nM. The proposed sensor exhibited high selectivity for glucose in the presence of various interfering species. The developed sensor was also successfully tested for the detection of glucose in human serum samples.
Mots clés
Cu doping, ZnO, electrochemistry, glucose, nanoparticles, non-enzymatic sensor
Référence
Molecules. 2021 Feb 10;26(4):