Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.
Fiche publication
Date publication
février 2021
Journal
Nature neuroscience
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOUMON Yannick, Pr POISBEAU Pierrick
Tous les auteurs :
Wahis J, Baudon A, Althammer F, Kerspern D, Goyon S, Hagiwara D, Lefevre A, Barteczko L, Boury-Jamot B, Bellanger B, Abatis M, Da Silva Gouveia M, Benusiglio D, Eliava M, Rozov A, Weinsanto I, Knobloch-Bollmann HS, Kirchner MK, Roy RK, Wang H, Pertin M, Inquimbert P, Pitzer C, Siemens J, Goumon Y, Boutrel B, Lamy CM, Decosterd I, Chatton JY, Rouach N, Young WS, Stern JE, Poisbeau P, Stoop R, Darbon P, Grinevich V, Charlet A
Lien Pubmed
Résumé
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.
Référence
Nat Neurosci. 2021 Feb 15;: