Calorie Restriction as a New Treatment of Inflammatory Diseases.
Fiche publication
Date publication
février 2021
Journal
Advances in nutrition (Bethesda, Md.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr QUILLIOT Didier, Pr PEYRIN-BIROULET Laurent, Dr DREUMONT Natacha
Tous les auteurs :
Kökten T, Hansmannel F, Ndiaye NC, Heba AC, Quilliot D, Dreumont N, Arnone D, Peyrin-Biroulet L
Lien Pubmed
Résumé
Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society. The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy intake and adiposity cause systemic inflammation, whereas calorie restriction (CR) without malnutrition, exerts a potent anti-inflammatory effect. The objective of this review was to provide an overview of different strategies used to reduce calorie intake, discuss physiological mechanisms by which CR might lead to improved health outcomes, and summarize the present knowledge about inflammatory diseases. We discuss emerging data of observational studies and randomized clinical trials on CR that have been shown to reduce inflammation and improve human health.
Mots clés
autophagy, caloric restriction, endoplasmic reticulum stress, fasting, gut microbiota, inflammatory disease, metabolic switch
Référence
Adv Nutr. 2021 Feb 8;: